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Functional Genomic Center Zurich Seminar Series

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Date

March 27, 2025 – June 16, 2026

Event location

UZH Irchel Campus, Y59 - G30/32/34
Web page

Organizer

Functional Genomic Center Zurich
Contact  ·  Web page

Description

The Functional Genomics Center Zurich (FGCZ) is a joint state-of-the-art research and training facility of the ETH Zurich and the University of Zurich. With our seminar series, we aim to increase the awareness of our users and the scientific community of the latest developments in the field of omics science.

Please be aware that photographs and/or film footage will be taken at these events and used within our digital channels . If you have any concerns, please speak to our staffs. Thanks.

Short link: ema.uzh.ch/RLTEL

Registration

  • FGCZ Proteomics workshop; Glycomics/glycoproteomics


    UZH Irchel

    Registration period has expired

    free

  • Students on Stage at FGCZ - 3rd Edition


    UZH Irchel

    Registration period has expired

    free

  • Unlock the Future: The Illumina Innovation Roadmap


    FGCZ

    Registration period has expired

    free
      Launching a New Wave of Illumina Technologies at FGCZ: TruPathTM Genome, Illumina 5-base Solution and Illumina Spatial Transcriptomics Agenda Welcome – Catharine Aquino, Unit Head Genomics, FGCZ The genome and beyond: unlocking deeper biology through multiomic & multimodal analysis - Joel Fellis, VP, Strategic Innovation and External Engagement, Illumina R&D Project highlights: data on TruPathTM Genome, Illumina 5-base Solution and Illumina Spatial Transcriptomics Q&A session Apero & Technology chat

     

  • Microscopic Scooping for Unbiased, Subcellular, Spatial Optoproteomic Discovery - Syncell at FGCZ


    UZH Irchel Campus, Y59 - G30

    Registration period has expired

    free
    Agenda 15:00 - 15:10        Welcome [Paolo Nanni, PhD] 15:10 - 15:50        Microscopic Scooping for Unbiased, Subcellular, Spatial Optoproteomic Discovery (30min + 10 min Q&A) [Matteo Cattaneo, PhD (SynCell)] 15:50 - 16:05        Break 16:05 - 16:55        Optoproteomics provides spatially resolved insights into chromatin biology (40min + 10min Q&A) [Cristiana Lungo, PhD (IZI Stuttgart)] 16:55 - 17:00        Wrap Up [Paolo Nanni, PhD] Abstracts: *Microscopic Scooping for Unbiased, Subcellular, Spatial Optoproteomic Discovery (Syncell) The quest for unbiased spatial proteomic discovery is critical in understanding the complex microenvironments within biological tissues. Traditional methods like proximity labeling and Laser Capture Microdissection (LCM) have their limitations: proximity labeling suffers from sample restriction (non-human models) and can lead to biased results due to incomplete labeling, while LCM is laborious and often lacks the precision needed for single-cell resolution. - Introduction to the Syncell Microscoop Mint: Discover its groundbreaking features and benefits along with a workflow overview. - Functional Biology Examples: Explore how the Microscoop Mint is being applied in diverse fields such as: Cell biology, Neurodegenerative disease, Drug discovery, Immuno-oncology, Developmental biology - Technical Insights: Learn how Microscoop Mint achieves spatial protein purification by introducing in situ subcellular photo-biotinylation of proteins at user-defined regions of interest (ROIs) one field of view (FOV) at a time for thousands of FOVs fully automatically. With mass spectrometry, Microscoop enables the discovery of subcellular proteomes in high sensitivity, specificity, and resolution. *Optoproteomics provides spatially resolved insights into chromatin biology (IZI Stuttgart) Polycomb Repressive Complex 2 (PRC2), a master regulator of chromatin organization and gene expression, is frequently deregulated in aggressive malignancies such as triple-negative breast cancer (TNBC). While cytoplasmic mistargeting of its catalytic subunit, Enhancer of Zeste Homolog 2 (EZH2), has been implicated in TNBC metastasis, whether this misregulation also extends to the spatial organization of nuclear PRC2 pools remains unexplored. Here, we uncover a novel mechanism of PRC2 regulation in TNBC cells, characterized by the accumulation of PRC2 in distinct, micron-sized nuclear bodies. By using unbiased spatial proteomics on these endogenous compartments, we identify a key molecular driver of this subnuclear compartmentalization and link this spatial organization to cellular processes critical for metastasis. These findings underscore the power of opto-proteomics in dissecting the local chromatin interactome, with high spatial resolution, and reveal an unrecognized layer of PRC2 regulation in TNBC, where subnuclear compartmentalization orchestrates functional outcomes essential for cancer progression.

  • 1st mzmine workshop at FGCZ: untargeted LC-MS data analysis for metabolomics and lipidomics

    This workshop will introduce non-target LC-MS2 data processing workflows in mzmine.
    Presenter:
    Dr. Steffen Heuckeroth, mzio GmbH, Bremen, Germany
    Analytical Chemist, CTO, and co-founder of mzio GmbH

    (Doors open: 12:45 PM)
    UZH Irchel Campus, Y59 - G30

    Registration period has expired

    free

  • Explore FGCZ - Empowering research with Science IT Infrastructure, Computational Experts and Bioinformatics


    UZH Irchel

    Registration period has expired

    free

  • Students on Stage at FGCZ - 2nd Edition

    (Doors open: 8:30 AM)
    UZH Irchel Campus, Y59 - G30

    Registration period has expired

    free

  • 10x Genomics User & Tech Day

    (Doors open: 11:45 PM)
    UZH Irchel Campus, Y59 - G30

    Registration period has expired

    free
    Join us to learn how single cell, spatial, and in situ technologies from 10x Genomics can help you push the boundaries of your research. During this day, we will not only cover the latest developments and launches, but also give insight into how researchers are using single-cell and spatial technologies in their cutting edge research. The User Day will begin with “office hours,” offering individual sessions with our field application specialist and scientific technical advisor, bookable in the morning. After a sponsored lunch, the afternoon is dedicated to the general session.

  • Singleron - Precision begins at the Single-Cell Level

    (Doors open: 11:45 AM)
    UZH Irchel Campus, FGCZ, Y59 - G30

    Registration period has expired

    free

  • FGCZ Proteomics workshop; Interaction Proteomics


    UZH Irchel Campus, Y59 - G32/34

    Registration period has expired

    free

  • Single-Cell Multiomics the SMART way - A BD Seminar


    UZH Irchel Campus, FGCZ, Y59 - G30

    Registration period has expired

    free

  • Explore AVITI24 with direct, in sample sequencing

    (Doors open: 1:45 PM)
    UZH Irchel, FGCZ - Y59-G30

    Registration period has expired

    free

  • FGCZ Proteomics workshop; Quantitative Proteomics


    UZH Irchel Campus, Y59 - G30

    Registration period has expired

    free

  • FGCZ Proteomics workshop; mass spectrometric characterization of intact proteins


    UZH Irchel Campus, Y59 - G30

    Registration period has expired

    free

  • FGCZ Proteomics workshop; Challenges and strategies in proteome-wide phosphorylation studies


    UZH Irchel

    Registration period has expired

    free
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